One of the Conference League clubs, 1. FSV Mainz 05, will face Sigma Olmütz from the Czech Republic in the round‑of‑16. The draw was held on Friday in Nyon. Mainz earned direct entry to the last‑16 by finishing high in the league, while Olmütz just managed a playoff slot, knocking out Lausanne to set up this tie.

Other round‑of‑16 matchups are: Alkmaar vs Sparta Prague; Lech Poznan vs Shakhtar Donetsk; NK Celje vs AEK Athens; HNK Rijeka vs Racing Strasbourg; Samsunspor vs Rayo Vallecano; AC Florence vs Rakow Częstochowa; and Crystal Palace vs AEK Larnaca.